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Many people with chronic symptoms are told their labs are “normal,” yet they still feel unwell. One overlooked reason is excess fibrin , a sticky structural protein your body naturally makes to heal injuries. It’s what happens when too much fibrin builds up over time and/or when your body can't break it down fast enough. Think of fibrin like scaffolding In small amounts, fibrin helps healing In excess, it can: Form protective shells (biofilms) around bacteria or viruses Hide infections from antibiotics and the immune system Stiffen blood vessels Interfere with circulation and healing This can help explain why some infections or symptoms never fully go away . Why does fibrin build up? There are two main reasons: 1. Some people make too much fibrin This can be genetic or driven by chronic inflammation (infections, mold exposure, autoimmune conditions). 2. Some people don’t break fibrin down well Their bodies don’t activate the enzymes needed to dissolve excess fibrin. Many people have both problems at once. How this can affect health Excess fibrin has been linked to: Chronic or recurrent infections Long COVID symptoms Brain inflammation (PANS/PANDAS) Fatigue and pain syndromes Pregnancy loss Heart and blood vessel disease Importantly, standard clotting tests often don’t detect this because they’re designed for emergencies, not slow buildup over years. Why treatment must be gentle and personalized Breaking down fibrin too quickly can: Release trapped toxins or microbes Increase inflammation temporarily Make symptoms flare That’s why the goal is balance , not “thinning the blood.” When done correctly, fibrin support: Helps the immune system see hidden infections Improves response to other treatments Supports long-term healing rather than short-term suppression Key Takeaway If you’ve tried “everything” and still feel stuck, the issue may not be what you’re treating - rather w hat’s been blocking your body from clearing it. Excess fibrin may be that missing piece. Action Plan If you think this may apply to you: Request the Hypercoag Reflexive3 Panel (Labcorp Test Code: 505443) Set up an appointment with your provider to discuss the results. Resources for Further Information: https://www.betterhealthguy.com/episode207 https://canadarna.com/products/boluoke-lumbrokinase Episode #207: Hypercoagulation with Ruth Kriz, MSN, APRN - BetterHealthGuy.com After nearly thirty years since the start of a serious chronic illness, BetterHealthGuy.com chronicles my journey through and recovery from Lyme Disease, mold illness, and the myriad of issues chro...